Author

Steffi Daniel

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

John D. HullemaniD· 5 shared Antonio J. Ortega· 3 shared Gracen E. CollieriD· 3 shared Bruce A. PosneriD· 2 shared Julian Yang· 2 shared Krista N. Thompson· 2 shared Melissa K. McCoyiD· 2 shared Sophia M. DiCesare· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersNeuroscience

John D. HullemanORCID

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Author profile →

5 papers

Recent·Most cited

An Inducible Model of RPE-Associated Hydroxyapatite Mineralization with Relevance to Drusen Formation in Age-Related Macular Degeneration

Julian Yang, Steffi Daniel, John D. Hulleman

This paper develops an inducible ARPE-19 cell model of hydroxyapatite mineralization, mimicking AMD drusen features and revealing transcriptional changes and mineral deposition inhibition.

bioRxiv · Oct 9, 2026 · PreprintCell Biology

Genetic removal of Nlrp3 protects against sporadic and R345W Efemp1-induced basal laminar deposit formation

Antonio J. Ortega, Steffi Daniel, Marian Renwick, Pravallika Kambhampati, Krista N. Thompson, Gracen E. Collier, Emily L. Baker, Hasan Zaki, John D. Hulleman

This study shows that removing Nlrp3 reduces basal laminar deposits in both a genetic mouse model and wild-type mice, suggesting a role for Nlrp3 in AMD pathology.

Cell Death and Disease · Nov 6, 2025Peer-reviewedImmunology

Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface

John D. Hulleman, Seungje Jeon, Sofia Bali, Sophia M. DiCesare, Ali Abbas, Steffi Daniel, Antonio J. Ortega, Gracen E. Collier, Julian Yang, Archishman Bhattacharyaa, Melissa K. McCoy, Łukasz A. Joachimiak, Bruce A. Posner

This paper identifies specific azo compounds that enhance HTRA1 abundance but have varying effects on its activity, suggesting potential therapeutic applications for diseases like AMD.

ACS Chemical Biology · Jul 30, 2025Peer-reviewedBiochemistry

GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology

Sophia M. DiCesare, Antonio J. Ortega, Gracen E. Collier, Steffi Daniel, Krista N. Thompson, Melissa K. McCoy, Bruce A. Posner, John D. Hulleman

The paper shows that GSK3 inhibition reduces fibulin-3 production and prevents AMD-like pathology in a mouse model of ML/DHRD.

JCI Insight · Aug 7, 2024Peer-reviewedNeuroscience

Important anatomical, age-related, and species considerations regarding ocular fibulin-3 (EFEMP1) analysis

Steffi Daniel, John D. Hulleman

The paper examines F3 expression and localization across species and age in ocular tissues, finding species-dependent and region-specific patterns, with age-related changes in F3 and ECM enzyme dynamics.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · May 13, 2024Peer-reviewedNeuroscience