Genetic removal of Nlrp3 protects against sporadic and R345W Efemp1-induced basal laminar deposit formation
Antonio J. Ortega, Steffi Daniel, Marian Renwick…·John D. Hulleman
This study shows that removing Nlrp3 reduces basal laminar deposits in both a genetic mouse model and wild-type mice, suggesting a role for Nlrp3 in AMD pathology.