Acute induction of IFNα is responsible for the attenuation of the live measles vaccine
Jerome M. Edwards, Steve Yoon, Jacqueline Brockhurst, Linda J. Rennick, William Paul Duprex, Isabelle Coppens, Andrew S Pekosz, Diane E. Griffin
This study identifies acute IFNα induction as the key mechanism by which the live measles vaccine is attenuated, revealing mutations in P/V/C and H genes responsible for this effect.
bioRxiv · Jun 9, 2025 · PreprintMicrobiology