Diane E. Griffin

This study shows that VEEV infection causes PARP-1 hyperactivation, leading to energy collapse and motor neuron death in mice and human cells.

This study identifies acute IFNα induction as the key mechanism by which the live measles vaccine is attenuated, revealing mutations in P/V/C and H genes responsible for this effect.

This study shows that reducing PAR-binding in ZAPS enhances antiviral activity against alphaviruses by disrupting replication complex formation and viral transcript levels.

This study shows that alphavirus nsP3 disrupts stress granule formation by removing ADP-ribosylation from G3BP1 and altering translation factor localization.