Single-cell analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes Ahr-dependent seboatrophy with elevated expression of infundibular Blimp1
Syeda Mashnia Tasnim, Subhash Solanki, Jyoti Bhuju, Lauren Thompson, Omar Skalli, Elizabeth A. Grice, Thomas R. Sutter, Thomas R. Sutter
This study shows TCDD induces Cyp1a1 in murine skin, enhancing sebaceous gland differentiation and lipid production before causing Ahr-dependent seboatrophy.
Toxicological Sciences · Oct 24, 2026Peer-reviewedCell Biology