Author

Sujan Devkota

University of Kansas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Masato MaesakoiD· 2 shared Michael S. WolfeiD· 2 shared Anita Saraf· 1 shared Arshad Ali NooraniiD· 1 shared Brian D. AckleyiD· 1 shared Caitlin Overmeyer· 1 shared Emily M. WilliamsiD· 1 shared Hung Nguyen DoiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Masato MaesakoORCID

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2 papers

Recent·Most cited

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

Parnian Arafi, Sujan Devkota, Emily M. Williams, Masato Maesako, Michael S. Wolfe

This study shows that FAD mutations in PSEN1 and APP cause stalled γ-secretase complexes, leading to synaptic degeneration, and that the F386S mutation specifically affects Aβ trimming without impairing endoproteolysis.

bioRxiv · Aug 30, 2024Biochemistry

Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes

Sujan Devkota, Rui Zhou, Vaishnavi Nagarajan, Masato Maesako, Hung Nguyen Do, Arshad Ali Noorani, Caitlin Overmeyer, Sanjay Bhattarai, Justin T. Douglas, Anita Saraf, Yinglong Miao, Brian D. Ackley, Yigong Shi, Michael S. Wolfe

This study shows that Alzheimer's mutations stabilize harmful enzyme-substrate complexes in gamma-secretase, leading to synaptic loss rather than the released Aβ peptides being the primary cause.

bioRxiv · Sep 8, 2023 · PreprintNeuroscience