Author

Emily M. Williams

Harvard UniversityORCID 0000-0002-8262-9181Unclaimed ORCID profile · follow to get notified of new preprints

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Biochemistry· 1

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Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:proteomics· 1

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Masato MaesakoiD· 1 shared Michael S. WolfeiD· 1 shared Parnian Arafi· 1 shared Sujan Devkota· 1 shared

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2024-2024 · peak 1/yr

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1 shared paperBiochemistry

Masato MaesakoORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivAug 30, 2024

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

Parnian Arafi, Sujan Devkota, Emily M. Williams…·Michael S. Wolfe

This study shows that FAD mutations in PSEN1 and APP cause stalled γ-secretase complexes, leading to synaptic degeneration, and that the F386S mutation specifically affects Aβ trimming without impairing endoproteolysis.

8 citations

C. elegansproteomics

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