NeurosciencebioRxivPreprint
Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes
Sujan Devkota, Rui Zhou, Vaishnavi Nagarajan…·Michael S. Wolfe
This study shows that Alzheimer's mutations stabilize harmful enzyme-substrate complexes in gamma-secretase, leading to synaptic loss rather than the released Aβ peptides being the primary cause.
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