Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis
Rui Hua, Yi Tian, Xuewei Wang, Frank A. Buttacavoli, Animesh Agarwal, Liang Ma, Manuel A. Riquelme, Hang Xu, Lidan Zhang, Teja Guda, Jun Zhang, Sumin Gu, Jean Xin Jiang
This study shows that targeting macrophage connexin 43 hemichannels reduces synovial inflammation and slows osteoarthritis progression in mice and human cells.
bioRxiv · Sep 9, 2026 · PreprintImmunology