Jun Zhang

KobA mediates kinesin-1-dependent transport of dynein-dynactin to microtubule plus ends

This study identifies KobA as a kinesin-1-binding protein that facilitates dynein-dynactin transport to microtubule plus ends in Aspergillus nidulans.

Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis

This study shows that targeting macrophage connexin 43 hemichannels reduces synovial inflammation and slows osteoarthritis progression in mice and human cells.

Evolutionary Origins and Synthetic Reconstruction of Gingerols

The paper identifies the evolutionary origins and reconstructs the biosynthetic pathway of gingerols using multi-omics approaches, enabling microbial production of 6-gingerol.

An Empirical Study on Quantifying Physical Energy Expenditure during High-intensity Exercise

This study develops a method to estimate physical energy expenditure during high-intensity exercise using non-invasive cardiovascular parameters and validates it against doubly labeled water measurements.

Pervasive splicing in a plant DNA virus

The paper identifies widespread RNA splicing in a plant DNA virus, showing it enhances viral infectivity by expanding the proteome.

PepCCD: A Contrastive Conditioned Diffusion Framework for Target-Specific Peptide Generation

PepCCD generates target-specific peptides using a contrastive conditioned diffusion framework, achieving strong binding affinity and improved diversity compared to existing methods.

Clade V MLO proteins are bona fide host susceptibility factors required for powdery mildew pathogenesis in Arabidopsis

DICAR-JP Regulates Ribosome Migration, a New Theory of Mitochondrial Protein Production

This paper identifies DICAR-JP as a functional domain that interacts with NAC to regulate OGDHL nascent peptide expression and mitochondrial translocation, proposing a new theory of ribosome migration in diabetic cardiomyopathy.

Combination of Imipridone ONC201 or ONC206 with Temozolomide and Radiotherapy in triple ITR therapy reduces intracranial tumor burden and prolongs survival in an orthotopic wild-type IDH GBM mouse model

This paper shows that combining ONC201 or ONC206 with temozolomide and radiotherapy significantly extends survival in a GBM mouse model compared to single treatments.

Quantification of collagen and associated features from H&E-stained whole slide pathology images across cancer types using a physics-based deep learning model

This paper introduces a deep learning model to predict collagen from H&E-stained images, enabling collagen quantification across cancer types and linking it to clinical outcomes.

Ovarian cancer cell cluster inhibits pancreatic cancer progression

This study shows that ovarian cancer cell clusters inhibit pancreatic cancer progression more effectively than single cells through inflammation promotion and macrophage polarization.

de novo diploid genome assembly using long noisy reads

PECAT improves diploid genome assembly from long noisy reads by correcting errors and resolving haplotypes, achieving high contiguity in cattle and human genomes.

DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing

The paper introduces ccsmeth, a deep-learning method for detecting DNA 5mCpGs using PacBio CCS, achieving high accuracy and AUC, and presents ccsmethphase for haplotype-aware methylation detection.

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.

Candidate urine biomarker discovery from only five pairs of samples before and after tumor resection in glioma patients

The paper identifies urine biomarkers in glioma patients by comparing pre- and post-tumor resection samples using LC-MS/MS, finding 27 proteins significantly changed.