Bone Response to Mechanical Loading is Highly Heritable and Correlates with Osteocyte Lacunar Morphology in Genetically Diverse Mouse Strains
Nicole Migotsky, Syeda Lamia, John T. Shuster, Surabhi Kumar, Charles R. Farber, Matthew J. Silva
This study shows that genetic background strongly influences bone response to mechanical loading in mice, with high heritability and correlations with osteocyte lacunar morphology.
bioRxiv · Nov 2, 2026 · PreprintBioengineering