Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and Inflammation
Snehal Shabrish, Swamini Patade, Sushma Shinde, Roohi Yelukar, Gorantla Venkata Raghuram, Relestina Simon Lopes, Naveen Kumar Khare, Indraneel Mittra
Circulating cell-free chromatin particles trigger a biphasic STING signaling program linking cell death to DNA damage and sterile inflammation, contributing to aging, cancer, and inflammatory diseases.
bioRxiv · Jul 31, 2026 · PreprintImmunology