Indraneel Mittra

Circulating cell-free chromatin particles trigger a biphasic STING signaling program linking cell death to DNA damage and sterile inflammation, contributing to aging, cancer, and inflammatory diseases.

The paper shows that apoptosis releases non-coding DNA (ncDNA) containing horizontally transferred DNA-protein complexes from various species, revealing human evolutionary heritage in ncDNA.

The paper shows that cell-free chromatin particles from cancer patients can transform mouse fibroblasts into cancer stem cells capable of forming tumors and expressing germline markers.

The paper shows that cell-free chromatin particles cause genomic DNA damage in an ROS-independent manner, suggesting new therapeutic targets for aging and degenerative diseases.

The paper shows that metastases form de novo in target organs when chromatin particles from dying cancer cells transform local cells into new cancers.

The paper shows that cell-free chromatin particles from dying cells trigger immune responses in human lymphocytes via the cGAS-STING pathway.

The paper shows that resveratrol and copper reduce multiple ageing and neurodegeneration markers by deactivating cell-free chromatin particles in mice.