Reduced prefrontal synaptic connectivity and disturbed oscillatory population dynamics in the CNTNAP2 model of autism
María T. Lázaro, Jiannis Taxidis, Tristan Shuman, Iris Bachmutsky, Taruna Ikrar, Rommel Andrew Santos, G. Mark Marcello, Apoorva L. Mylavarapu, Swasty Chandra, Allison Foreman, Rachna Goli, Duy Tran, Nikhil Sharma, Michelle Azhdam, Hongmei Dong, , Peyman Golshani
This study investigates the effects of CNTNAP2 loss-of-function mutations in mice, finding reduced synaptic connectivity and altered oscillatory dynamics in the prefrontal cortex associated with autism-like behaviors.
Cell Reports · May 1, 2019Peer-reviewedNeuroscience