Targeting cellular cathepsins inhibits hepatitis E virus infection
M. Kloehn, T. Burkard, J. Janzen, J. A. Schrader, A. Goemer, R. J. P. Brown, V. L. Dao Thi, V. Kinast, Y. Brueggemann, D. Todt, E. Steinmann
This study identifies lysosomal cathepsins, particularly CTSL, as critical for HEV entry and demonstrates the antiviral efficacy of the pan-cathepsin inhibitor K11777.
bioRxiv · Nov 3, 2023 · PreprintCell Biology