Author

E. Steinmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 10 Organism:human· 5 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:virus· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Todt· 12 shared S. Pfaender· 9 shared T. L. Meister· 7 shared A. Krawczyk· 6 shared Y. Brueggemann· 5 shared U. Dittmer· 4 shared A. Kratzel· 3 shared B. Becker· 3 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

12 shared papersMicrobiology

D. Todt

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes

N. Frericks, R. J. P. Brown, B. M. Reinecke, M. Herrmann, Y. Brueggemann, D. Todt, C. Miskey, F. Vondran, E. Steinmann, T. Pietschmann, J. A. Sheldon

This study identifies cell culture adaptive mutations in HCV that enhance replicative fitness in cell lines but reduce virion production in primary human hepatocytes by boosting antiviral responses.

bioRxiv · Nov 22, 2023 · PreprintMolecular Biology

Targeting cellular cathepsins inhibits hepatitis E virus infection

M. Kloehn, T. Burkard, J. Janzen, J. A. Schrader, A. Goemer, R. J. P. Brown, V. L. Dao Thi, V. Kinast, Y. Brueggemann, D. Todt, E. Steinmann

This study identifies lysosomal cathepsins, particularly CTSL, as critical for HEV entry and demonstrates the antiviral efficacy of the pan-cathepsin inhibitor K11777.

bioRxiv · Nov 3, 2023 · PreprintCell Biology

A high-content RNA-based imaging assay reveals integrin beta 1 as a cofactor for cell entry of non-enveloped hepatitis E virus

R. M. Fu, Z. Engels, J. A. Wheis, J. Muerle, M. Kloehn, D. Todt, J. Hu, E. Steinmann, T. Boettler, P.-Y. Lozach, S. M. Lemon, V. L. Dao Thi

This study identifies integrin beta 1 as a cofactor for naked hepatitis E virus entry, revealing distinct endocytic pathways for naked and enveloped HEV particles.

bioRxiv · Oct 27, 2023 · PreprintMicrobiology

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

J. Schuhenn, T. L. Meister, D. Todt, T. Bracht, K. Schork, J.-N. Billaud, C. Elsner, N. Heinen, Z. Karakoese, S. Haid, S. Kumar, L. Brunotte, M. Eisenacher, J. Chen, Z. Yuan, , S. Pfaender

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

bioRxiv · May 20, 2021 · PreprintCell Biology

Comparable environmental stability and disinfection profiles of the currently circulating SARS-CoV-2 variants of concern B.1.1.7 and B.1.351

T. L. Meister, J. Fortmann, D. Todt, N. Heinen, A. Ludwig, Y. Brueggemann, C. Elsner, U. Dittmer, S. Pfaender, E. Steinmann

This study compares the environmental stability and disinfection profiles of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the wildtype, finding comparable susceptibility to disinfection and surface stability.

bioRxiv · Apr 7, 2021Microbiology

A realistic touch-transfer method reveals low risk of transmission for SARS-CoV-2 by contaminated coins and bank notes

D. Todt, T. L. Meister, B. Tamele, J. Howes, D. Paulmann, B. Becker, F. H. Brill, M. Wind, J. Schijven, B. Mhlekude, C. Goffinet, A. Krawczyk, J. Steinmann, S. Pfaender, Y. Brueggemann, E. Steinmann

This study assesses the risk of SARS-CoV-2 transmission via contaminated coins and banknotes using a novel touch transfer method and shows it is unlikely under typical conditions.

bioRxiv · Apr 2, 2021Microbiology

Disinfection of SARS-CoV-2 contaminated surfaces of personal items with UVC-LED disinfection boxes

M. Bormann, M. Alt, L. Schipper, L. van de Sand, M. Otte, T. L. Meister, U. Dittmer, O. Witzke, E. Steinmann, A. Krawczyk

This study evaluates the effectiveness of UVC-LED disinfection boxes in inactivating SARS-CoV-2 on personal item surfaces, showing significant viral load reduction after 3 minutes of exposure.

bioRxiv · Mar 3, 2021Microbiology

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

A. Kratzel, J. N. Kelly, Y. Brueggemann, J. Portmann, P. V'kovski, D. Todt, N. Ebert, E. Steinmann, R. Dijkman, G. Zimmer, S. Pfaender, V. Thiel

This study identifies autophagy-related host factors as conserved targets for coronavirus replication using CRISPR screens and shows that immunophilin inhibitors can block viral replication.

bioRxiv · Feb 24, 2021Microbiology

Virucidal efficacy of different formulations for hand and surface disinfection targeting SARS CoV-2

K. Steinhauer, T. L. Meister, D. Todt, A. Krawczyk, L. Passvogel, B. Becker, D. Paulmann, B. Bischoff, M. Eggers, S. Pfaender, F. Brill, E. Steinmann

This study shows that three disinfectant formulations effectively inactivate SARS-CoV-2, supporting their use as preventive measures against enveloped viruses.

bioRxiv · Nov 8, 2020Microbiology

Comparison of the in vitro-efficacy of different mouthwash solutions targeting SARS-CoV-2 based on the European Standard EN 14476

K. Steinhauer, T. L. Meister, D. Todt, A. Krawczyk, L. Passvogel, B. Becker, D. Paulmann, B. Bischoff, S. Pfaender, F. Brill, E. Steinmann

This study evaluates the in vitro efficacy of chlorhexidine and octenidine mouthwashes against SARS-CoV-2 using EN 14476 standards, finding octenidine effective within 15 seconds.

bioRxiv · Oct 25, 2020Microbiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

S. Pfaender, K. B. Mar, E. Michailidis, A. Kratzel, D. Hirt, P. V'kovski, W. Fan, N. Ebert, H. Stalder, H. Kleine-Weber, M. Hoffmann, H. H. Hoffmann, M. Saeed, R. Dijkman, E. Steinmann, , V. Thiel

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

Nature Microbiology · Jul 23, 2020Peer-reviewedMicrobiology

Holder Pasteurization Inactivates SARS-CoV-2 in Human Breast Milk

C. Conzelmann, R. Gross, T. L. Meister, D. Todt, A. Krawczyk, U. Dittmer, S. Stenger, J. Muench, E. Steinmann, J. A. Mueller, S. Pfaender

This study shows that Holder pasteurization inactivates SARS-CoV-2 in human breast milk, offering a safe method for infected mothers to breastfeed.

bioRxiv · Jun 17, 2020 · PreprintMicrobiology

Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols

A. Kratzel, D. Todt, P. V'kovski, S. Steiner, M. L. Gultom, T. T. N. Thao, N. Ebert, M. Holwerda, J. Steinmann, D. Niemeyer, R. Dijkman, G. Kampf, C. Drosten, E. Steinmann, V. Thiel, S. Pfaender

The paper tests the virucidal activity of WHO-recommended hand rubs and alcohols against SARS-CoV-2, showing efficient inactivation for all tested products.

bioRxiv · Mar 10, 2020 · PreprintMicrobiology