R. J. P. Brown

This study identifies lysosomal cathepsins, particularly CTSL, as critical for HEV entry and demonstrates the antiviral efficacy of the pan-cathepsin inhibitor K11777.

This study uses 3D spatiotemporal analysis to show that SARS-CoV-2 infection in hamsters leads to monocyte-derived macrophage infiltration, vascular damage, and virus clearance, followed by tissue remodeling and fibrosis.

This study shows that SARS-CoV-2 entry via TMPRSS2 or endolysosomal cathepsins affects viral replication, immune response, and genome evolution.

This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.

This study identifies temporally structured transcriptional changes in HCV-infected human hepatocytes, revealing both antiviral and pro-viral programs that may contribute to viral persistence.