Author

T. E. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

C. Yang· 2 shared S. L. Spencer· 2 shared C. R. Ill· 1 shared C. Tian· 1 shared N. K. Jacobsen· 1 shared V. Nangia· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

C. Yang

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

T. E. Hoffman, C. Yang, V. Nangia, C. R. Ill, S. L. Spencer

The paper shows that multiple cancer types rapidly escape MAPK inhibitors by forming mutagenesis-prone subpopulations through ATR and FA pathway dependencies.

bioRxiv · Mar 17, 2023Cancer Biology

Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

c. yang, C. Tian, T. E. Hoffman, N. K. Jacobsen, S. L. Spencer

This study tracks single melanoma cells' response to BRAF inhibitors and identifies non-genetic mechanisms enabling rapid drug escape within 3 days of treatment.

bioRxiv · Mar 15, 2020Cell Biology