C. Tian

HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin

This study identifies HKDC1 as a prometastatic enzyme in liver cancer that stabilizes β-catenin under hypoxia, enhancing cancer stemness.

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment

This paper develops a dual-targeted nanoparticulate drug delivery system (SJNP) combining SN38 and JQ-1 to enhance triple-negative breast cancer treatment by disrupting DNA repair and mitochondrial function.

Self-amplifying ROS-sensitive SN38 Dimeric Prodrug nanoparticles for Combined Chemotherapy and Ferroptosis in Cancer Treatment

This paper develops SN38-CA@FC NPs, a ROS-sensitive dimeric prodrug nanoparticle that combines chemotherapy and ferroptosis to treat cancer, showing potent antitumor activity in cell lines and mouse models.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

Hybrid Adipocyte-Derived Exosome Nano Platform for Potent Chemo-Phototherapy in Targeted Hepatocellular Carcinoma

This paper develops a hybrid adipocyte-derived exosome platform for targeted chemo-phototherapy of hepatocellular carcinoma, showing enhanced drug delivery and tumor growth inhibition.

SANTA FE OXA: Self-assembled oxaliplatin nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

This paper develops a nanomicelle, SANTA FE OXA, that enhances cancer chemotherapy by inducing ferroptosis and reducing systemic toxicity.

Differences in Hepatocellular Iron Metabolism Underlie Sexual Dimorphism in Hepatocyte Ferroptosis

This study identifies sex differences in hepatocyte ferroptosis, showing males are more susceptible due to differences in iron metabolism and FSP1 regulation.

Levy statistics define anxiety and depression in mice subjected to chronic stress

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

Brain Organoid Computing for Artificial Intelligence

The paper develops Brainoware, a living AI hardware using 3D brain organoids to compute nonlinear equations and demonstrate learning capabilities.

Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

This study identifies RRM2 and RRM2B as key players in hepatoblastoma progression and drug response, showing their dynamic switching and impact on relapse.

Spatiotemporal Dynamics of Vcam1 Regulates Cholangiocarcinoma Mass Expansion and Tumor Dissemination under Growth-suppressive Peritumoral Myofibroblasts

This study shows that Vcam1 expression in cholangiocarcinoma cells is regulated by peritumoral myofibroblasts, promoting tumor dissemination while suppressing growth.

Engineering human spinal microphysiological systems to model opioid-induced tolerance

This paper develops human spinal microphysiological systems to model opioid-induced tolerance and hyperalgesia, showing altered neural activity and receptor downregulation with prolonged opioid exposure.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

RNA Methylome Reveals the m6A-Mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-Withering

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

Elevated ozone concentration and nitrogen addition increase poplar rust severity by shifting the phyllosphere microbial community

This study shows elevated ozone and nitrogen addition increase poplar rust severity by altering phyllosphere microbial communities, with clone-specific responses observed.

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Dextran Sodium Sulfate-Induced Ulcerative Colitis

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

The compound of baicalein, wogonin, and oroxylin-A inhibits EMT in A549 cell line via PI3K/AKT-TWIST1-glycolysis pathway

This study identifies baicalein, wogonin, and oroxylin-A as active compounds in TFAE that inhibit EMT in A549 cells via the PI3K/AKT-TWIST1-glycolysis pathway.

Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

Comprehensive molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells

This study identifies altered gene expression and cell interactions in oocytes and cumulus cells of PCOS patients, highlighting dysregulated microtubule genes and transposable elements.

Peptide Ancestry Informative Markers in Uterine Neoplasms from Women of European, African and Asian Ancestry

The paper identifies peptide ancestry informative markers (pAIMs) that correlate with ancestry in uterine neoplasms, showing they can accurately determine ancestry proportions with high precision.

Single-nucleus RNA-seq resolves spatiotemporal developmental trajectories in the tomato shoot apex

This study uses snRNA-seq to create a high-resolution spatiotemporal gene expression atlas of tomato shoot apex cells, identifying distinct cell types and developmental regulators.

Identification of microbial markers across populations in early detection of colorectal cancer

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions

This study examines how SARS-CoV-2 mutations affect protein structures and intraviral interactions, identifying mutations that cause structural changes and alter binding affinity and hot spots.

Requirement of the antimicrobial peptide CRAMP for macrophages to eliminate phagocytosed E. coli through an autophagy pathway

This study shows CRAMP is required for macrophages to eliminate phagocytosed E. coli via autophagy, involving ATG5, LC3-II, and LAMP-1.

Novel non-transposable-element regulation patterns of KZFP family reveal new drivers of its rapid evolution

This study identifies new regulatory patterns of KZFP family zinc fingers that drive their rapid evolution by binding non-transposable element regions and positively regulating gene expression.

Identification of sulfenylated cysteines in Arabidopsis thaliana proteins using a disulfide-linked peptide reporter

This study identifies sulfenylated cysteines in Arabidopsis thaliana using a transgenic Yap1 probe, revealing over 1,000 proteins with sulfenylated residues.

Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

This study tracks single melanoma cells' response to BRAF inhibitors and identifies non-genetic mechanisms enabling rapid drug escape within 3 days of treatment.

Behaviour and cold hardiness of the purple stem borer in winter, colonizing more northerly latitudes

This study examines the overwintering behavior and cold hardiness of the purple stem borer in its newly colonized northern range, identifying its survival strategies and potential distribution limits.