Self-assembly of multi-component mitochondrial nucleoids via phase separation
M. Feric, T. G. Demarest, J. Tian, D. L. Croteau, V. A. Bohr, T. Misteli
This study shows that mitochondrial nucleoids assemble via phase separation, with TFAM and mtDNA forming viscoelastic droplets, and links this process to mitochondrial dysfunction in HGPS.
bioRxiv · Jul 20, 2020Cell Biology