J. Tian

Bridging scale-up to transplantation: pluripotent stem cell-derived pancreatic islet encapsulation in emulsion-generated high concentration alginate beads

This study develops a scalable encapsulation method for pluripotent stem cell-derived pancreatic islets, showing improved cell recovery and in vivo functionality during transplantation.

Deep contrastive learning enables genome-wide virtual screening

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

Genome Assembly of Docynia delavayi Provides New Insights into α-Farnesene Biosynthesis

This study reports the first high-quality genome of Docynia delavayi and identifies key genes and transcription factors involved in α-farnesene biosynthesis, a major aroma compound in its fruit.

Aurora Kinase A Inhibition plus Tumor Treating Fields Suppress Glioma Cell Proliferation in a Cilium-Independent Manner

This paper shows that combining Aurora Kinase A inhibition with Tumor Treating Fields reduces glioma cell proliferation, and this effect is not dependent on cilia.

Episymbiotic bacterium induces intracellular lipid droplet production in its host bacteria

This study investigates the interaction between Saccharibacteria TM7x and its host XH001, revealing TM7x-induced lipid droplet formation in XH001 and its protective role under stress.

Structural insights into a single semi-clathrate hydrate formed in a confined environment of porous protein crystal.

The paper identifies a single semi-clathrate structure formed on a ferritin crystal surface and shows how temperature affects its stability and formation mechanism.

Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery

This paper discovers Vibrio natriegens as a microbial platform for efficient formic acid utilization and remodeled it to enhance formate consumption and indigoidine production.

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant SMO and GLI into Glioma Primary Cilia

This study shows increased ARL13B expression drives active and inhibitor-resistant SMO and GLI into glioma cilia, promoting treatment resistance.

Transparent and stretchable metal nanowire composite recording microelectrode arrays

This paper develops stretchable, transparent microelectrode arrays using gold-coated silver nanowires, demonstrating high optical transparency, low impedance, and stable performance for biomedical applications.

GABA-receptors are a new druggable target for limiting disease severity, lung viral load, and death in SARS-CoV-2 infected mice

This study shows that GABA-receptor agonists reduce disease severity, lung viral load, and death in SARS-CoV-2 infected mice.

Ultra-small bispecific fusion protein augments tumor penetration and treatment efficacy for pancreatic cancer

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

Multifunctional flexible electro-optical arrays for simultaneous spatiotemporal cardiac mapping and modulation

This paper introduces flexible electro-optical devices for simultaneous cardiac mapping and modulation, demonstrating their functionality in real-time spatiotemporal control of cardiac activity.

Planting graphene quantum dots in PEGylated nanoparticles for enhanced and multimodal in vivo imaging of tumor

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

Inside-out tracking and projection mapping for robot-assisted transcranial magnetic stimulation

This paper improves robot-assisted TMS by implementing inside-out tracking and projection mapping for better coil placement accuracy.

JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum

This study shows JQ-1 reduces liver granuloma size and egg production in Schistosoma japonicum-infected mice by inhibiting reproductive system development and gene expression.

Genomic insights into the phylogeny and biomass-degrading enzymes of rumen ciliates

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity

This study shows TTFields reduce cilia in glioma cells, enhancing TMZ toxicity, and that ciliogenesis timing affects treatment outcomes.

Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure

The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.

Response of whitefly to the wild tomato Solanum habrochaites

This study examines how the wild tomato Solanum habrochaites affects the survival, fecundity, and gene expression of the whitefly Bemisia tabaci, revealing stress gene induction and potential for pest control.

GABA administration limits viral replication and pneumonitis in a mouse model of COVID-19

This study shows that GABA treatment reduces viral load and lung inflammation in a mouse model of COVID-19, suggesting GABA-Rs as a potential therapeutic target.

IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis through the MAPK Signaling Pathway

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

Flexible and transparent silver nanowire structures for multifunctional electrical and optical biointerfacing

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

GABA administration prevents severe illness and death following coronavirus infection in mice

This study shows that GABA administration reduces severe illness and death in mice infected with MHV-1, suggesting its potential as a treatment for coronavirus infections.

Neonicotinoids stimulate H2-limited methane emission in Periplaneta americana through the regulation of gut bacterium community

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

Eurycomanone regulates lipid metabolism by activating the cAMP/PKA pathway

This study shows that eurycomanone promotes lipolysis and reduces fat accumulation by activating the cAMP/PKA pathway in 3T3-L1 cells and C57BL/6J mice.

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation

This study shows JQ-1 reduces liver fibrosis in Schistosoma-infected mice by inhibiting JAK2/STAT3 signaling in hepatic stellate cells.

Self-assembly of multi-component mitochondrial nucleoids via phase separation

This study shows that mitochondrial nucleoids assemble via phase separation, with TFAM and mtDNA forming viscoelastic droplets, and links this process to mitochondrial dysfunction in HGPS.

Vegetation and Microbes Interact to Preserve Organic Matter in Wooded Peatlands

The paper investigates how vegetation and microbes interact to preserve organic matter in wooded peatlands, finding that slow-growing microbes and plant-induced recalcitrant carbon reduce carbon loss despite climate stressors.