Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections
M. T. Heemskerk, C. J. Korbee, J. Esselink, C. Carvalho dos Santos, S. van Veen, I. F. Gordijn, F. Vrieling, K. V. Walburg, C. G. Engele, K. Dijkman, L. Wilson, F. A. Verreck, M. C. Haks, T. H. Ottenhoff
This study identifies two antipsychotic drugs, Pimozide and Fluspirilene, as potential host-directed therapies for Mycobacterium tuberculosis and Salmonella enterica infections by modulating autophagy and lysosomal responses.
bioRxiv · Jun 5, 2021Immunology