L. Wilson

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer

This study compares KRASG12C and KRASG12D mutant NSCLC models, finding that KRASG12D relies more on the PI3K-AKT-mTOR pathway, suggesting tailored combination therapies.

Evolution of a large periplasmic disk in Campylobacterota flagella facilitated efficient motility alongside autoagglutination

The paper investigates the function of a large periplasmic disk in Campylobacter jejuni flagella, showing it facilitates motility and autoagglutination by bracing the motor during filament disentanglement.

ST3Gal1 synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer

This study shows ST3Gal1 promotes immune evasion in prostate cancer by synthesizing Siglec ligands, and its activity can be modulated by enzalutamide.

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

Complexes of tubulin oligomers and tau form an intervening network cross-bridging microtubules into bundles

The paper identifies an intervening network of tubulin-tau complexes that cross-link microtubules into bundles, revealing a new role for tubulin in stabilizing MT fascicles and preventing tau leakage in neurodegeneration.

Long-term population decline of a genetically homogenous continental-wide top Arctic predator

This study uses genetic analysis to show that Snowy Owls across North America form a genetically homogenous population with no differentiation, despite long-distance dispersal, and reveals a long-term population decline linked to climate change.

Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

This study identifies two antipsychotic drugs, Pimozide and Fluspirilene, as potential host-directed therapies for Mycobacterium tuberculosis and Salmonella enterica infections by modulating autophagy and lysosomal responses.

Saccharide Analysis of Onion Outer Epidermal Walls

The paper analyzes the saccharide composition of onion outer epidermal walls using multiple methods and finds that homogalacturonan makes up about 50% of the polysaccharides.

Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms

This study investigates the structure and mechanism of two marine-derived β-lactamase-lactonase enzymes, revealing their structural conservation and diverse reaction mechanisms.

Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse and widespread in the environment.

The paper identifies a broad phylogenetic diversity of B3 MBLs in environmental microbes and shows that a variant (B3-RQK) is sensitive to clavulanic acid due to a lysine residue in its active site.

Pectin methylesterase selectively softens the onion epidermal wall yet reduces acid-induced creep

The paper treats onion epidermal walls with pectin methylesterase, showing it softens the wall but reduces acid-induced creep.

Altered active control of step width in response to mediolateral leg perturbations while walking

This study examines how humans adjust active control of step width during walking in response to mediolateral leg perturbations, finding gradual changes in control with repeated exposure.

Detection of a novel insect specific flavivirus across ecologically diverse populations of Aedes aegypti on the Caribbean Island of Saint Lucia

The paper surveys Aedes aegypti and Ae. albopictus across Saint Lucia, finding a novel insect-specific flavivirus with high prevalence in Ae. aegypti.