CRTC1-MAML2 Establishes a PGC1α-IGF1 Circuit that Confers Vulnerability to PPARγ Inhibition
A. M. Musicant, K. Parag-Sharma, W. Gong, M. Sengupta, A. Chatterjee, E. C. Henry, Y.-H. Tsai, M. Hayward, S. Sheth, R. Betancourt, T. Hackman, R. J. Padilla, J. S. Parker, J. Giudice, C. A. Flaveny, , A. L. Amelio
This study identifies a CRTC1-MAML2-driven transcriptional circuit involving PGC-14 and IGF-1 that makes mucoepidermoid carcinoma cells vulnerable to PPARγ inhibition.
bioRxiv · Jun 3, 2020 · PreprintCancer Biology