W. Gong

This study analyzes honeybee wing kinematics during takeoff, revealing key parameters and the role of hinged wings in thrust generation.

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.

The paper investigates how Rad26 interacts with lesion-arrested Pol II and identifies Elf1's role in enhancing this interaction for transcription-coupled repair.

This study solves the structures of AlaDC and SerDC, identifies key residues for activity and specificity, and shows engineered variants improve theanine production.

This paper introduces a method to enable multicolor live-cell STED imaging with at least 4 colors using phasor analysis to separate dyes of the same spectrum.

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

This study compares the effects of bariatric surgery and calorie restriction on obesity-driven triple-negative breast cancer in mice, finding calorie restriction more effective in reversing tumor growth.

The paper quantifies food web dynamics in a low export ecosystem, finding microbial recycling dominates carbon flow with minimal export due to slow turnover and high detrital background.

This study shows ANGPTL4 promotes epidermal stem cell proliferation and migration, enhancing wound re-epithelialization in mice.

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

This study identifies two Synechococcus genomes from an iron-limited region that lack nitrate and nitrite assimilation genes, suggesting reliance on recycled nitrogen forms.

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

This study identifies ELOF1 as a factor that promotes transcription-coupled repair and prevents genome instability by modulating transcription and recruiting repair factors.

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

The paper investigates how membrane protein aggregation and immobilization affect lipid order in T cells, revealing lipid-mediated recruitment of signaling proteins like Lck.

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

This study shows CRAMP is required for macrophages to eliminate phagocytosed E. coli via autophagy, involving ATG5, LC3-II, and LAMP-1.

This study identifies a CRTC1-MAML2-driven transcriptional circuit involving PGC-14 and IGF-1 that makes mucoepidermoid carcinoma cells vulnerable to PPARγ inhibition.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

This study identifies 53 QTLs associated with Verticillium wilt resistance in cotton using CSSLs and detects 32 novel QTL hotspot regions, providing a foundation for genetic analysis and breeding programs.