SPECT/CT imaging, biodistribution and radiation dosimetry of a 177Lu-DOTA-integrin αvβ6 cystine knot peptide in a pancreatic cancer xenograft model
S. Sachindra, T. Hellberg, S. Exner, S. Prasad, N. Beindorff, S. Rogalla, R. Kimura, S. S. Gambhir, B. Wiedenmann, C. Groetzinger
This study evaluates a 177Lu-labeled integrin αvβ6-targeting knottin peptide for imaging and therapy of pancreatic cancer using xenograft models, showing high tumor accumulation and moderate kidney uptake.
bioRxiv · Mar 23, 2021Cancer Biology