Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates
S. Blazquez, I. Sanchez-Burgos, J. Ramirez, T. Higginbotham, M. M. Conde, R. Collepardo-Guevara, A. R. Tejedor, J. R. Espinosa
This study shows that the location and number of LARKS in proteins affect the viscoelastic properties and aging of biomolecular condensates, with multiple LARKS leading to gel-like behavior.
bioRxiv · Dec 14, 2022Biophysics