J. Ramirez

Virulence and transmission biology of the widespread, ecologically important pathogen of zooplankton, Spirobacillus cienkowskii

This study experimentally quantifies the virulence and transmission dynamics of Spirobacillus cienkowskii, revealing it as highly virulent and requiring host death for horizontal transmission, with potential vertical transmission via Daphnia egg cases.

In-vitro reconstitution of Herpes Simplex Virus 1 fusion identifies low pH as a fusion co-trigger

This study reconstitutes HSV-1 membrane fusion in vitro and identifies low pH as a co-trigger, along with a host receptor, for efficient fusion.

Nanomolar interactions of alpha-synuclein fibrils to tau determined by FCS

The paper investigates interactions between tau and alpha-synuclein using FCS, finding stronger binding with fibrillar alpha-synuclein than monomers, without affecting tau aggregation.

Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates

This study shows that the location and number of LARKS in proteins affect the viscoelastic properties and aging of biomolecular condensates, with multiple LARKS leading to gel-like behavior.

Time-dependent material properties of ageing biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

This study compares computational methods to measure viscoelasticity of biomolecular condensates in simulations, finding that SSRMI and OS techniques outperform BT in efficiency and accuracy.

Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

The paper shows that inter-protein β-sheets increase RNA-binding protein condensate viscosity and alter network connectivity, leading to gelation, but RNA can slow this process.

Increased Brain Volumetric Measurement Precision from Multi-Site 3D T1-weighted 3T Magnetic Resonance Imaging by Correcting Geometric Distortions

This study shows that correcting geometric distortions in multi-site MRI improves volumetric measurement precision in brain scans.

Non-structural carbohydrate concentrations in woody organs, but not leaves, of temperate and tropical tree angiosperms are independent of the "fast-slow" plant economic spectrum

Dual RNA modulation of protein mobility and stability within phase-separated condensates

This study uses a coarse-grained model to show RNA modulates phase-separated condensate stability and transport properties through dual mechanisms depending on RNA concentration and length.

Statistical Agnostic Mapping: A Framework In Neuroimaging Based On Concentration Inequalities

This paper introduces a framework for neuroimaging using concentration inequalities to improve model validation and hypothesis testing with small sample sizes.

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

This study shows androgen signaling increases ACE2 levels, contributing to severe COVID-19 in men, and suggests androgen receptor inhibition as a potential treatment.

Structural characterization of tau in fuzzy tau:tubulin complexes

This study characterizes the structure of tau in fuzzy tau:tubulin complexes using fluorophore probes and compares it to cryo-EM models of tau:MT complexes.

Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles

This study shows Listeria monocytogenes secretes biologically active extracellular vesicles containing virulence factors like LLO and PI-PLC, which contribute to cytotoxicity in macrophages.