A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives
Y. Nagasawa, M. Nakayama, Y. Kato, Y. Ogawa, S. D. Aribam, Y. Tsugami, T. Iwata, O. Mikami, A. Sugiyama, M. Onishi, T. Hayashi, M. Eguchi
This paper introduces a method to convert bacterial pathogens into live vaccines using unnatural amino acid-auxotrophic suicide derivatives, showing enhanced immunogenicity and safety.
bioRxiv · Sep 14, 2023Microbiology