H. Nakai

This study identifies OpgD as the enzyme responsible for synthesizing CβG16, a key virulence factor in Xanthomonas, revealing a novel transglycosylation mechanism with implications for developing new agrichemicals.

The paper functionally and structurally analyzes the cyclization domain of a cyclic β-1,2-glucan synthase, revealing it produces cyclic β-1,2-glucans through transglycosylation without hydrolysis and proposes it belongs to a new glycoside hydrolase family.

This study identifies AAV capsids that enhance gene delivery to renal tubules and podocytes, showing context-dependent effectiveness based on delivery route and disease state.

The paper identifies OpgG and OpgD from E. coli as β-1,2-glucanases with distinct activities, revealing a new glycoside hydrolase family and a unique reaction mechanism for OpgD.

This study shows that AoAgtA, a GPI-anchored α-amylase in Aspergillus oryzae, cleaves -1,4-glycosidic bonds in the spacer region of cell wall -1,3-glucan, reducing its molecular weight.

This study shows that CXCL13-producing CD4+ T cells induce tertiary lymphoid structures (TLSs) in ovarian cancer, increasing CD8+ T cell and B cell infiltration and improving patient prognosis.

This study identifies frequent PIK3CA mutations in eutopic endometrium of ovarian clear cell carcinoma patients, showing high mutation rates and intratumor heterogeneity.

This study uses quantum-mechanical simulations to reveal a hydroxide ion mechanism for primary proton transfer in bacteriorhodopsin, showing the role of specific internal water molecules in the process.