Y. Takahashi

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

This study identifies a MAP-kinase, BdMPK5, as critical for CO2-induced stomatal closure in Brachypodium, using forward genetics and structural modeling.

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

This study shows that mechanical signaling via membrane tension and mechanosensitive ion channels links leading process extension to somal translocation during neuronal migration.

The paper examines circadian and circatidal rhythms in a freshwater snail, finding that both tidal and nontidal populations exhibit circatidal rhythms after exposure to a simulated tidal cycle, with tidal populations showing more circatidal oscillating genes.

This study creates a genetically engineered mouse model of NUT carcinoma by inducing the Brd4::Nutm1 fusion gene, showing it can initiate aggressive tumors with features similar to human NC.

This study quantifies phenotypic plasticity and developmental noise in Drosophila simulans and finds a positive correlation between them, suggesting they contribute to evolvability.

The paper examines genetic variation and developmental noise in foraging traits of Drosophila lutescens, finding shared genetic basis for variation in locomotive activity and resource preferences.

This study shows that Trp oxidation at the N-terminus of D1 protein enhances FtsH-mediated degradation during high-light stress in PSII repair.

The paper combines gene supplementation and genome editing to treat spinal muscular atrophy in mice, showing long-term therapeutic benefits.

This study identifies the genomic basis of female-limited morphs and male mimicry in damselflies, revealing structural variants and transposable element activity driving these phenotypes.

This study identifies two viral strategies to evade bacterial retrons: supplying tRNATyr to counteract retron 78 and using Rad to degrade retron noncoding RNA precursors.

This study investigates the non-catalytic role of MPK12 in CO2-induced stomatal responses, showing that its interaction with HT1 is CO2/HCO3--dependent and kinase activity-independent.

This study identifies IMPDH as a potential target for anti-monkeypox virus agents by showing that compounds targeting this enzyme inhibit MPXV replication more effectively than existing treatments.

This study identifies disorganized basement membrane zone architecture and MMP2 overexpression in dermal fibroblasts as contributors to melanocyte loss in vitiligo.

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

A low carbohydrate diet suppresses neuroendocrine tumor onset and progression by reducing insulin signaling and PI3K-Akt-mTOR pathway activity in mouse models and correlates with better prognosis in patients.

This study shows that AoAgtA, a GPI-anchored α-amylase in Aspergillus oryzae, cleaves -1,4-glycosidic bonds in the spacer region of cell wall -1,3-glucan, reducing its molecular weight.

This study uses Raman imaging to show how avermectin production correlates with mycelial differentiation stages in Streptomyces avermitilis under different culture conditions.

The paper introduces a method to detect frequency-dependent selection by analyzing genotype similarity's effect on fitness components using regression analysis in Arabidopsis and damselfly data.

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

This study identifies CreRH22, a plastidial DEAD-box RNA helicase, as essential for high light acclimation in Chlamydomonas reinhardtii by enhancing ribosome biogenesis.

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

The paper shows that two doses of mRNA vaccine generate cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant, which are retained and contribute to enhanced antibody responses after a third dose.

The paper introduces a mutation in the algal cytochrome b6f complex that alters its pH dependency, affecting electron transfer under acidic conditions.

This study identifies markers for skeletal muscle-derived extracellular vesicles (SkM-EVs) and shows they mainly function within the muscle microenvironment rather than contributing significantly to plasma EVs.

The paper presents a cryo-EM structure of a homodimeric chloroplast PSI from Chlamydomonas reinhardtii, revealing its organization and interactions with plastocyanin and Lhca9.

The paper investigates ATP release patterns under hypotonic stress in mammary cells, identifying VRACs as a conduit for ATP release in undifferentiated cells.