Overcoming ibrutinib resistance by targeting phosphatidylinositol-3-kinase signaling in diffuse large B-cell lymphoma
N. Jain, O. Havranek, R. K. Singh, T. Khashab, F. Shirazi, F. Samaniego, L. Sehgal
This study identifies phosphatidylinositol-3-kinase-beta upregulation as a mechanism of ibrutinib resistance in diffuse large B-cell lymphoma and shows that targeting this pathway with KA2237 can overcome resistance.
bioRxiv · Jan 28, 2019 · PreprintCancer Biology