Author

L. Sehgal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Organism:human· 3 Assay:metabolomics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. Chavdoula· 4 shared P. N. Tsichlis· 4 shared V. Anastas· 4 shared A. La Ferlita· 3 shared G. I. Laliotis· 3 shared S. Singh· 3 shared A. Orlacchio· 2 shared A. Sircar· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

E. Chavdoula

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6 papers

Recent·Most cited

Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4

E. Chavdoula, V. Anastas, A. La Ferlita, J. Aldana, G. Carota, M. Spampinato, B. Soysal, I. Cosentini, S. Parashar, A. Sircar, G. Nigita, L. Sehgal, M. A. Freitas, P. N. Tsichlis

This study identifies KDM2B's role in regulating amino acid metabolism through interactions with ncPRC1.1, MYC, and ATF4, revealing a metabolic network linked to poor prognosis in TNBC.

bioRxiv · Jul 7, 2023Cancer Biology

Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program.

G. I. Laliotis, E. Chavdoula, V. Anastas, S. Singh, A. I. Kenney, S. Achaya, J. S. Yount, L. Sehgal, P. N. Tsichlis

The paper was withdrawn due to concerns about the integrity of the reported results on alternative splicing of U2AF2.

bioRxiv · Aug 12, 2021 · PreprintCancer Biology

Multiomics Integration Elucidates Metabolic Modulators of Drug Resistance in Lymphoma

F. Choueiry, S. Singh, X. Sun, S. Zhang, A. Sircar, A. Hart, L. Alinari, N. Epperla, R. Baiocchi, J. Zhu, L. Sehgal

This study identifies metabolic reprogramming in ibrutinib-resistant DLBCL using multi-omics integration, revealing the BTK-PI3K-AKT-IL4I1 axis as a key driver of drug resistance.

bioRxiv · Jan 7, 2021 · PreprintCancer Biology

IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2.

G. I. Laliotis, A. Kenney, E. Chavdoula, A. Orlacchio, A. K. Kaba, A. La Ferlita, V. Anastas, C. Tsatsanis, J. D. Beane, L. Sehgal, V. Coppola, J. S. Yount, P. N. Tsichlis

The paper was withdrawn due to concerns about the validity of the reported alternative splicing mechanism of U2AF2 and potential data manipulation.

bioRxiv · Dec 26, 2020Cancer Biology

IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.

G. I. Laliotis, E. Chavdoula, M. D. Paraskevopoulou, A. D. Kaba, A. La Ferlita, S. Singh, V. Anastas, S. Alaimo, A. Orlacchio, K. A. Nair, V. Taraslia, I. Vlachos, M. Capece, A. Hatzigeorgiou, D. I. Palmieri, , P. N. Tsichlis

The paper was withdrawn due to concerns about the validity of the reported splicing mechanism and data integrity.

bioRxiv · Jul 14, 2020Cancer Biology

Overcoming ibrutinib resistance by targeting phosphatidylinositol-3-kinase signaling in diffuse large B-cell lymphoma

N. Jain, O. Havranek, R. K. Singh, T. Khashab, F. Shirazi, F. Samaniego, L. Sehgal

This study identifies phosphatidylinositol-3-kinase-beta upregulation as a mechanism of ibrutinib resistance in diffuse large B-cell lymphoma and shows that targeting this pathway with KA2237 can overcome resistance.

bioRxiv · Jan 28, 2019 · PreprintCancer Biology