FOXC1 and FOXC2 maintain mitral valve endothelial cell junctions, extracellular matrix, and lymphatic vessels to prevent myxomatous degeneration
C. Tan, S. Kurup, Y. Dyakiv, T. Kume
This study shows that Foxc1 and Foxc2 are essential for maintaining mitral valve structure by preserving endothelial cell junctions, extracellular matrix, and lymphatic vessels, preventing myxomatous degeneration.
bioRxiv · Aug 30, 2023Cell Biology