C. Tan

Early evolution of BA.2.86 sheds light on the origins of highly divergent SARS-CoV-2 lineages

The paper investigates the evolutionary origins of the BA.2.86 SARS-CoV-2 variant, finding it evolved through multiple transmission chains and recombination, not a single chronic infection.

Endothelial cell dysfunction and retinal arteriolar narrowing in young adults with elevated blood pressure

This study links endothelial cell dysfunction with retinal arteriolar narrowing in young adults with elevated blood pressure, identifying GRB2 as a potential molecular link.

Heterogenous organization in condensates of multiple transcription factors in embryonic stem cells

This study uses molecular dynamics simulations to analyze the heterogeneous behavior of condensates formed by four master transcription factors in embryonic stem cells, revealing distinct roles for each factor in condensate formation.

The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans

The study reconstructs the Yunxian 2 cranium and shows it belongs to the Homo longi clade, likely including Denisovans, and is closely related to the H. sapiens clade.

FOXC1 and FOXC2 maintain mitral valve endothelial cell junctions, extracellular matrix, and lymphatic vessels to prevent myxomatous degeneration

This study shows that Foxc1 and Foxc2 are essential for maintaining mitral valve structure by preserving endothelial cell junctions, extracellular matrix, and lymphatic vessels, preventing myxomatous degeneration.

GENESIS CGDYN: large-scale coarse-grained MD simulation with dynamicload balancing for heterogeneous biomolecular systems

The paper introduces GENESIS CGDYN, a large-scale coarse-grained MD simulation tool with dynamic load balancing for heterogeneous biomolecular systems, demonstrating its application to IDP droplet fusions and large droplet formation.

Micelle-like clusters in phase-separated Nanog condensates: A molecular simulation study

This study uses molecular simulations to show that Nanog forms micelle-like clusters in condensates via hydrophobic interactions, with surface domains mediating condensate bridging and DNA recruitment.

Context-dependent functions of mitochondria protein quality control in lung

This study shows that mitochondrial protein quality control via LONP1 is context-dependent in lung epithelial cells, affecting proliferation, differentiation, and migration through the integrated stress response.

Inflammatory ER Stress Responses Dictate the Immunopathogenic Progression of Systemic Candidiasis

This study shows that IRE1 hyperactivation in myeloid cells during Candida albicans infection drives renal immunopathology and mortality, and inhibiting IRE1 reduces inflammation and improves survival.

Repulsive interaction and secondary structure of highly charged proteins in regulating biomolecular condensation

This study uses molecular dynamics simulations to investigate how Hero11 proteins regulate TDP-43 condensation through repulsive and attractive interactions, proposing three mechanisms for preventing pathological aggregation.

Vascular endothelial growth factor A contributes to the increasing of mammalian respiratory epithelial permeability induced by Pasteurella multocida infection

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

The complex roles of genomic DNA modifications of bacteriophage T4 in resistance to nuclease-based defense systems of E. coli

The paper investigates how genomic modifications in phage T4 DNA affect its resistance to nuclease-based defense systems in E. coli, revealing roles beyond simple DNA degradation prevention.

The Nucleocapsid Protein Of SARS-CoV-2, Combined With ODN-39M, Is A Potential Component For An Intranasal Bivalent Pancorona Vaccine

This paper evaluates a bivalent intranasal vaccine candidate combining SARS-CoV-2 N protein and ODN-39M, showing cross-reactive immunity against SARS-CoV-1 and enhanced Th1 response when combined with RBD.

Lung spatial profiling reveals a T cell signature in COPD patients with fatal SARS-CoV-2 infection

The paper uses spatial transcriptomic and proteomic profiling to analyze lung tissues from COPD patients who died of COVID-19, revealing increased T-lymphocytes and altered immune responses.

Frequency dependent growth of bacteria in living materials

This study investigates how bacteria grow in 3D hydrogels and finds that their growth depends on disturbance frequency and hydrogel density, explained through stochastic resonance theory.

Role of Water-bridged Interactions in Metal Ion Coupled Protein Allostery

This study reveals that water-bridged interactions facilitate Ca2+ binding and allostery in calmodulin by reducing energy landscape ruggedness and enabling asymmetric EF-hand responses.

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

A nano-liquid hub integrating growth and immune-evasion signaling to promote cell survival

The paper identifies GEM, a nano-liquid hub that integrates growth and immune-evasion signaling to enhance cell survival in mice.

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

The paper shows oversized cells increase proteasome-mediated protein degradation to maintain size homeostasis by reducing growth efficiency.

Implementation of residue-level coarse-grained models in GENESIS for large-scale molecular dynamics simulations

The paper implements residue-level coarse-grained models in GENESIS to enable large-scale molecular dynamics simulations of biomolecules, improving computational efficiency and handling heterogeneous systems.

Direct carbon capture for production of high-performance biodegradable plastic by cyanobacterial cell factory

This paper develops a cyanobacterial cell factory to produce high-performance biodegradable plastic from CO2, achieving a 270-fold increase in PLA titer through metabolic engineering and high-density cultivation.

Dissecting the roles of Haspin and VRK1 in Histone H3 threonine-3 phosphorylation during mitosis

This study investigates the roles of Haspin and VRK1 in phosphorylating histone H3 during mitosis, finding that VRK1 does not directly phosphorylate H3T3 or H3S10, while Haspin is essential for H3T3ph.

Size-scaling promotes senescence-like changes in proteome and organelle content

The paper investigates how cell size scaling affects proteome organization and organelle content, linking these changes to senescence-like features in human cells.

Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors

This paper develops a mouse model of PanNETs driven by Cdk5 and shows its relevance to human tumors, supporting Cdk5 as a therapeutic target.

PLURIPOTENT STEM CELL-DERIVED CARDIOVASCULAR PROGENITORS DIFFFERENTIATED ON LAMININ 221 REGENERATE AND IMPROVE FUNCTION OF INFARCTED SWINE HEARTS

This paper differentiates pluripotent stem cells into cardiovascular progenitors on laminin 221 and shows improved heart function in infarcted pigs.

The Kinetic Landscape of Nucleosome Assembly: A Coarse-Grained Molecular Dynamics Study

This study uses molecular dynamics simulations to analyze the kinetic landscape of nucleosome assembly, revealing transition networks and the role of DNA bending and histone association in positioning sequences.

Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

This study shows that NUR77/Nr4a1 negatively regulates B cell clonal dominance in early T-dependent immune responses to maintain diversity in the germinal center niche.

A quantitative view of strategies to engineer cell-selective ligand binding

This paper develops a quantitative model to evaluate strategies for enhancing cell-selective ligand binding through affinity, valency, and multi-ligand approaches.

Early induction of SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

The paper examines the relationship between SARS-CoV-2 specific T cell responses and disease severity in COVID-19 patients, finding that early T cell induction correlates with mild disease and faster viral clearance.

Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38

The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.