Identification of molecular and clinical ALS subgroups based on TDP-43 loss of function molecular markers from population-based patient-derived iPS motor neurons
T. L. Cheng, shaili tripathi, Yike Guo, Parimala Vedula, R. Li, Michael Potanin, Nidhi Soley, April Yujie Yan, Ishan Vatsaraj, Carl Harris, Joseph L. Greenstein, Casey Overby Taylor, Alyssa N. Coyne, Jeffrey D. Rothstein
The paper identifies molecular and clinical subgroups of ALS using TDP-43 loss-of-function markers from patient-derived iPS motor neurons, revealing distinct disease severity and clinical outcomes.
bioRxiv · Jan 7, 2026 · PreprintNeuroscience