R. Li

Cost-effective genomic prediction for fertility traits: A comparison of machine learning and conventional models using low-coverage sequencing in Holstein heifers

This study compares machine learning and conventional models for genomic prediction of fertility traits in Holstein heifers using low-coverage sequencing data, finding that KRR_GRM improves accuracy over traditional methods when using only genomic data.

Identification of molecular and clinical ALS subgroups based on TDP-43 loss of function molecular markers from population-based patient-derived iPS motor neurons

The paper identifies molecular and clinical subgroups of ALS using TDP-43 loss-of-function markers from patient-derived iPS motor neurons, revealing distinct disease severity and clinical outcomes.

Realizing Mechanical Frustration at the Nanoscale Using DNA Origami

This paper uses DNA origami to create a nanoscale metastructure that can switch between frustrated and non-frustrated mechanical states, with distinct free energy profiles.

Metabolic regulation of misfolded protein import into mitochondria

This study shows that Snf1/AMPK inhibits misfolded protein import into mitochondria and promotes mitochondrial biogenesis under glucose starvation, protecting mitochondrial fitness in yeast and human cells.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Differential prevalence and risk factors for infection with coronaviruses in bats collected during 2020 in Yunnan Province, China

The paper examines CoV prevalence in bats from Yunnan Province, identifying new SARSr-CoVs and factors influencing their distribution and zoonotic risk.

Rational design of HER2-targeted combination therapies to reverse drug resistance in fibroblast-protected HER2+ breast cancer cells.

This study identifies PAI1 and PLK1 as predictors of fibroblast-mediated resistance in HER2+ breast cancer and shows that targeting these proteins with lapatinib improves treatment efficacy.

Expanding the Triangle of U: The genome assembly of Hirschfeldia incana provides insights into chromosomal evolution, phylogenomics and high photosynthesis-related traits

This paper presents an improved genome assembly of Hirschfeldia incana, revealing insights into chromosomal evolution, phylogenomics, and genes related to high photosynthesis traits.

Natural selection and evolution of mitochondrial genome in terrestrial and aquatic turbellarians

This study examines the mitochondrial genome evolution in turbellarians, finding greater selection pressure in aquatic species and identifying NAD4 as a key gene under positive selection.

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Single-cell imaging of the lytic phage life cycle in bacteria

This study uses time-lapse imaging to analyze phage infection dynamics in bacteria, revealing heterogeneity and its impact on phage fitness.

The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain

The paper determines the structure of the thioesterase domain of SulM and its complex with the upstream carrier protein domain, revealing a constrained active site for β-lactam formation.

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH

The paper identifies L3HYPDH as an IFN-stimulated gene that inhibits EV71 replication by targeting its IRES-mediated translation.

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

A comprehensive two-hybrid analysis to explore the L. pneumophila effector-effector interactome

The paper uses a yeast two-hybrid screen to identify novel effector-effector interactions in L. pneumophila, doubling the known number of such interactions.

Calcineurin promotes adaptation to chronic stress through two distinct mechanisms

This study shows calcineurin (CN) helps yeast adapt to chronic stress through two distinct mechanisms involving Crz1 and Crz1-independent pathways.

CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under control of antigen sensing in microwell arrays

This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.

R-Loop Functions in Brca1-Associated Mammary Tumorigenesis

This study shows that reducing R-loops in Brca1-knockout mice increases ER-expressing tumors but does not affect tumor incidence.

TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport

The paper identifies TDP43 aggregation at ER-exit sites as a cause of impaired ER-to-Golgi transport in ALS.

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

A functional medicine and food homology composition discovery based on disease-related target and data mining against cardiac remodeling

This study identifies β-ecdysterone as a functional compound that counteracts cardiac remodeling by enhancing NRF2, revealing cross-talk between cardiac remodeling and neuromodulation.

Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease

This study identifies novel chemokine ligand-receptor pairs involved in immune cell recruitment in cutaneous lupus by combining spatial transcriptomics, proteomics, and immunological assays.

DNA Nanostar Structures with Tunable Auxetic Properties

This paper designs DNA nanostar structures with tunable auxetic properties using DNA origami and sliding mechanisms, enabling reconfigurable nanoscale metamaterials.

Camel milk affects serum metabolites by modulating the intestinal microflora

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins in invasive protrusion formation at the mammalian fusogenic synapse.

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccine

The paper designs an intranasal pan-coronavirus vaccine using epitopes from SARS-CoV-2 and zoonotic coronaviruses, showing immune responses in mice but needing further cross-reactivity testing.

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.