Ligand bias underlies differential signaling of multiple FGFs via FGFR1
K. A. Karl, K. Hristova, P. Krejci, N. Del Piccolo, T. Light, T. Roy, P. Dudeja, V.-C. Ursachi, B. Fafilek
The paper quantifies differential signaling of FGF4, FGF8, and FGF9 through FGFR1, revealing ligand bias and conformational differences in receptor dimers.
bioRxiv · Jan 6, 2022Biophysics