T. Roy

CD44/Integrin β1 association drives fast motility on HA substrates

This study shows that CD44/Integrin β1 association enables faster cell motility on HA substrates by forming smaller, weaker focal adhesions.

Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

Measuring RBC deformability and its heterogeneity using a fast microfluidic device

The paper introduces a microfluidic device to measure RBC deformability and Young's modulus, showing stiffer RBCs deflect more and enabling sorting based on deformability.

Transferrin Receptor 1 is Required for CD4+ T Cell Iron-Dependent Response During Acute Toxoplasma gondii Infection

This study shows that iron acquisition by CD4+ T cells is essential for their activation and long-term protection against Toxoplasma gondii infection.

Precision-engineered biomimetics: the human fallopian tube

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

Size-selective mortality fosters evolutionary changes in collective learning across ontogeny and decision-making in zebrafish, Danio rerio

This study shows size-selective harvesting in zebrafish alters learning and decision-making abilities across ontogeny, with reduced learning speed in large-harvested fish and faster decision-making in the same line.

Identification of potential inhibitors of cutaneous Melanoma and Non-Melanoma skin cancer cells through in vitro and in silico screening of a small library of Phenolic compounds

This study screens a small library of phenolic compounds in vitro and in silico to identify potential inhibitors of melanoma and non-melanoma skin cancer cells, finding several compounds with significant antitumor activity and selectivity.

Ligand bias underlies differential signaling of multiple FGFs via FGFR1

The paper quantifies differential signaling of FGF4, FGF8, and FGF9 through FGFR1, revealing ligand bias and conformational differences in receptor dimers.

Size-selective mortality fosters ontogenetic changes in collective risk-taking behaviour in zebrafish, Danio rerio

This study shows size-selective mortality in zebrafish alters risk-taking behavior, with small-harvested fish being bolder and large-harvested fish showing more variability in boldness across life stages.

Evidence for a growth zone for deep subsurface microbial clades in near-surface anoxic sediments

The paper shows that certain deep subsurface microbial clades increase in population size in shallow marine sediments, challenging the idea that they remain in a state of prolonged torpor during burial.

Ensemble projections of global ocean animal biomass with climate change

The paper compares multiple models to project changes in global ocean animal biomass under climate change scenarios, finding significant declines under high emissions.