Quantitative analysis and genome-scale modeling of human CD4+ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways
P. Sen, S. B. A. Andrabi, T. Buchacher, M. M. Khan, U. Ullah, T. Lindeman, M. Alves Amaral, V. Hinkkanen, E. Kemppainen, A. M. Dickens, O. Rasool, T. Hyotylainen, R. Lahesmaa, M. Oresic
This study uses genome-scale modeling and lipidomics to show that glycosphingolipid pathways are specifically regulated in Th17 cells during differentiation and are critical for their effector functions.
bioRxiv · Jan 29, 2021 · PreprintImmunology