TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines
N. Honke, T. Lowin, B. Opgenoorth, N. Shaabani, A. Lautwein, J. R. Teijaro, M. Schneider, G. Pongratz
This study shows that TLR9-activated B cells produce catecholamines, enhancing their regulatory function through adrenergic receptor activation and increased IL-10 and co-inhibitory ligand expression.
bioRxiv · May 24, 2020 · PreprintImmunology