M. Schneider

Human chronic inflammation is orchestrated by spatially restricted inflammation-activated Dendritic cells

This study identifies a novel inflammation-associated dendritic cell state in human chronic inflammation and shows its spatial restriction and therapeutic relevance.

Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics

The paper uses spatial transcriptomics and proteomics to identify claudin-4 as a theranostic target in pancreatic cancer, showing its increased expression and suitability for molecular imaging.

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

Cell-binding IgM in CSF is distinctive of multiple sclerosis and targets the iron transporter SCARA5

The paper identifies cell-binding IgM in CSF that targets SCARA5 in multiple sclerosis, linking it to complement activation and T cell infiltration.

EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma

This study identifies EMP3 as a regulator of EGFR/CDK2 signaling in glioblastoma by stabilizing EGFR and promoting its oncogenic activity.

Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds

The paper investigates how spatial confinement in MAP scaffolds affects immune cell recruitment and wound healing, finding that larger pores promote a balanced macrophage response and better regeneration.

Immune cells employ intermittent integrin-mediated traction forces for 3D migration

This study shows immune cells switch between amoeboid and contractile migration modes in dense matrices, using integrin-mediated forces to navigate steric hindrance.

ORF3c is expressed in SARS-CoV-2 infected cells and suppresses immune activation by inhibiting innate sensing

This study identifies ORF3c as an immune evasion factor of SARS-CoV-2 that suppresses innate sensing by inhibiting RIG-I and MDA5 signaling.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition

This study identifies chr8 gains and 4E-BP1 expression as prognostic markers in Ewing sarcoma, showing they drive cancer progression by promoting proliferation and sensitizing to CDK4/6 inhibitors.

A balance between pro-inflammatory and pro-reparative macrophages is observed in regenerative D-MAPS

The paper investigates the immunomodulatory effect of D-MAPS and finds a balance between pro-inflammatory and pro-reparative macrophages in regenerative scaffolds.

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis

This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.

IRON REGULATORY PROTEIN (IRP)-MEDIATED IRON HOMEOSTASIS IS CRITICAL FOR NEUTROPHIL DEVELOPMENT AND DIFFERENTIATION IN THE BONE MARROW

This study shows that IRP-mediated iron homeostasis is essential for neutrophil development and differentiation in the bone marrow, with no effect on monocyte counts.

Effects of Hydroxychloroquine and Azithromycin on iPSC-derived Cardiomyocytes: Considerations for the Treatment of COVID-19 Patients

This study investigates the effects of HCQ and AZM on iPSC-derived cardiomyocytes, finding that their combination significantly increases cardiotoxicity and electrophysiological dysfunction.

NRF1 Association with AUTS2-Polycomb Mediates Specific Gene Activation in the Brain

The paper identifies NRF1's role in PRC1.3 recruitment to chromatin and shows AUTS2 mutations disrupt gene regulation and motor neuron differentiation.

Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

This study shows that Langerhans islets in pancreatic tumors promote anti-tumor immunity but impair glycemic control, and identifies T2DM and HbA1c as predictors of chemotherapy response.

AutoSmarTrace: Automated Chain Tracing and Flexibility Analysis of Biological Filaments

AutoSmarTrace automates chain tracing and persistence length calculation from single-molecule images, showing agreement with ground truth and previous methods.

TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines

This study shows that TLR9-activated B cells produce catecholamines, enhancing their regulatory function through adrenergic receptor activation and increased IL-10 and co-inhibitory ligand expression.

Combining Crowdsourcing and Deep Learning to Assess Public Opinion on CRISPR-Cas9

The paper analyzes Twitter data on CRISPR-Cas9 using BERT and statistical methods to track public sentiment trends and link sentiment changes to specific events.

Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a non-human primate model

This study evaluates the efficacy of secretory IgA2 and dimeric IgA2 antibodies against ETEC in a non-human primate model, finding that oral SIgA2 significantly reduced diarrheal attack rates.

Neutrophils Suppress Mucosal-Associated Invariant T Cells

This study shows neutrophils suppress MAIT cell activation via cell-contact and H2O2, while activated MAIT cells induce neutrophil death through TNF, revealing a bidirectional regulatory feedback loop.

Nod-like receptors are critical for gut-brain axis signaling

This study identifies Nod1 and Nod2 as critical regulators of gut-brain axis signaling, showing their role in stress-induced behavioral and physiological changes.

Transcriptional analysis defines TCR and cytokine-stimulated MAIT cells as rapid polyfunctional effector T cells that can coordinate the immune response

This study compares the transcriptional and effector responses of human MAIT cells to TCR and cytokine stimulation, revealing distinct functional outcomes.

Role of Innate-like Lymphocytes in the Pathogenesis of Community Acquired Pneumonia

This study examines the role of innate-like lymphocytes in community-acquired pneumonia, finding that their abundance correlates with clinical outcomes and immune responses.

Low Rate of Somatic Mutations in a Long-Lived Oak Tree

The paper sequenced two branches of a 234-year-old oak tree and found few somatic mutations, suggesting shoot meristems are mutation-resistant.