Author

T. Markou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

A. Clerk· 2 shared H. O. Alharbi· 2 shared J. J. Cull· 2 shared M. A. Hardyman· 2 shared P. E. Glennon· 2 shared P. H. Sugden· 2 shared S. J. Fuller· 2 shared S. T. Cooper· 2 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

A. Clerk

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2 papers

Recent·Most cited

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

H. O. Alharbi, M. A. Hardyman, J. J. Cull, T. Markou, S. T. Cooper, P. E. Glennon, S. J. Fuller, P. H. Sugden, A. Clerk

This study shows that BRAF in cardiomyocytes is essential for male mouse cardiac hypertrophy and fibrosis in hypertension but has opposing effects in physiological hypertrophy, with sex-specific differences.

bioRxiv · Sep 7, 2022Physiology

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

A. Clerk, D. N. Meijles, M. A. Hardyman, S. J. Fuller, S. P. Chothani, J. J. Cull, S. T. Cooper, H. O. Alharbi, K. Vanezis, L. E. Felkin, T. Markou, S. J. Leonard, S. W. Shaw, O. J. Rackham, S. A. Cook, , P. H. Sugden

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

bioRxiv · Aug 14, 2021Biochemistry