Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsets
S. H. Andrews, T. Maughon, R. A. Marklein, S. L. Stice
This study shows that acidosis-primed MSCs produce EVs that enhance regulatory T cell frequencies and uptake, suggesting acidosis could improve MSC-EV therapeutic potential.
bioRxiv · Apr 30, 2020Bioengineering