Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq
I. L. Morgan, S. J. McKie, R. Kim, Y. Seol, J. Xu, G. Harami, T. Maxwell, K. Neuman
This study develops SHAN-seq to map type II topoisomerase cleavage sites on DNA with high sensitivity, revealing hundreds of sites and enzyme-specific variations.
bioRxiv · May 17, 2024 · PreprintBiochemistry