R. Kim

Evaluation of intracochlear pressure and distribution during fluid application in cochlea models and human petrous bone

This study compares substance application techniques in cochlea models and human petrous bone, finding that a second-hole method reduces intracochlear pressure and improves distribution.

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

This study shows that SARS-CoV-2 ORF8 protein modulates lung inflammation and disease severity in mice by affecting macrophage infiltration and function.

Social transmission of valence-linked new knowledge without firsthand experience in mice

This study introduces an improved social learning test in mice that allows learning of valence-linked knowledge without firsthand experience, showing differential hippocampal involvement in learning and recall.

Loss of Skeletal Muscle Pyruvate Dehydrogenase Induces Lactic Acidosis and Adaptive Anaplerotic Compensation via Pyruvate-Alanine Cycling and Glutaminolysis

This study shows that loss of skeletal muscle pyruvate dehydrogenase causes lactic acidosis and early death, but high-fat diets can mitigate these effects.

Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin

The paper identifies genes in Escherichia coli that affect susceptibility to a cell wall-degrading toxin from Pseudomonas aeruginosa, revealing the role of lipopolysaccharide in modulating toxin toxicity.

Antibacterial potency of Type VI amidase effector toxins is dependent on substrate topology and cellular context

This study identifies functional determinants of Tae1, a bacterial T6SS amidase toxin, showing that its antimicrobial potency depends on substrate topology and cellular context.

Oxo-M and 4-PPBP Delivery via Multi-Domain Peptide Hydrogel Toward Tendon Regeneration

This study develops a multi-domain peptide hydrogel for controlled delivery of Oxo-M and 4-PPBP to enhance tendon regeneration in vivo.

S18-phosphorylation of USP7 regulates interaction with TCEAL4 that defines specific complexes and potentially distinct functions.

SCARF1-induced efferocytosis plays an immunomodulatory role in humans, and autoantibodies targeting SCARF1 are produced in patients with systemic lupus erythematosus

This study shows SCARF1 is an apoptotic cell receptor on dendritic cells in humans, and autoantibodies against SCARF1 are linked to impaired efferocytosis in SLE patients.

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

A Deep Learning Approach for Rapid Mutational Screening in Melanoma

This paper develops a deep learning model to detect BRAF mutations in melanoma histopathology images using whole slide images from 256 patients, achieving AUC scores of 0.96 and 0.72.

Development of a Coronavirus Disease 2019 Nonhuman Primate Model Using Airborne Exposure

This study infects nonhuman primates with SARS-CoV-2 via airborne exposure and compares disease progression across species.

Disruption of Adaptive Immunity Enhances Disease in SARS-CoV-2 Infected Syrian Hamsters

This study shows that disrupting adaptive immunity in Syrian hamsters worsens SARS-CoV-2 disease, but a neutralizing antibody reduces infection even in immunosuppressed animals.

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

This study shows that activating FFA4 reduces airway resistance in mouse models of inflammation and human lung tissue, suggesting it could be a therapeutic target for asthma and COPD.

A glucose-dependent spatial patterning of exocytosis inhuman β-cells is disrupted in type 2 diabetes

This study shows that glucose-dependent spatial organization of exocytosis in human β-cells is disrupted in type 2 diabetes.

Nijmegen Breakage Syndrome (NBS) is a telomeropathy: analysis of telomere length in NBS homo- and heterozygotes and humanized Nbs ice

This study shows that Nijmegen Breakage Syndrome (NBS) is a telomeropathy, with reduced telomere length in patients, and explores its dual role in cancer susceptibility and survival.

Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

The paper compares immune cell infiltration in primary and metastatic breast tumors, finding reduced immune cell abundance but increased M2-like macrophages in metastases.