Epigenetic regulation of protein translation in KMT2A-rearranged AML
A. Lenard, H. M. Xie, S. S. Riedel, Z.-F. Yuan, N. Zhu, T. Neff, K. M. Bernt
This paper evaluates combinations of DOT1L and EZH2 inhibitors in KMT2A-rearranged AML, finding synergistic effects with a protein translation inhibitor but not with EZH2 inhibition.
bioRxiv · Oct 2, 2019Cancer Biology