Cancer BiologybioRxiv
Epigenetic regulation of protein translation in KMT2A-rearranged AML
A. Lenard, H. M. Xie, S. S. Riedel…·K. M. Bernt
This paper evaluates combinations of DOT1L and EZH2 inhibitors in KMT2A-rearranged AML, finding synergistic effects with a protein translation inhibitor but not with EZH2 inhibition.