Cancer BiologybioRxiv
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia
J. Ung, S.-F. Tan, T. E. Fox…·D. J. Feith
This study evaluates the anti-leukemic effects of LCL-805, an acid ceramidase inhibitor, in AML cell lines and patient samples, showing it promotes iron-dependent cell death by antagonizing Akt signaling.
DOI 10.3390/cancers15245866