Author

H.-G. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 2 Biophysics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

X. Liang· 3 shared F. Tian· 2 shared G. Wang· 2 shared J. M. Flanagan· 2 shared M. C. Bewley· 2 shared X. Liu· 2 shared Y. Takahashi· 2 shared Y. Ye· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

X. Liang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

J. Ung, S.-F. Tan, T. E. Fox, J. J. Shaw, M. Taori, B. J. Horton, U. Golla, A. Sharma, Z. M. Szulc, H.-G. Wang, C. E. Chalfant, M. C. Cabot, D. F. Claxton, T. P. Loughran, D. J. Feith

This study evaluates the anti-leukemic effects of LCL-805, an acid ceramidase inhibitor, in AML cell lines and patient samples, showing it promotes iron-dependent cell death by antagonizing Akt signaling.

bioRxiv · Oct 21, 2023Cancer Biology

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

M. Matsui, L. E. Lynch, I. Distefano, A. Galante, N. Gomez-Banoy, H.-G. Wang, A. R. Gade, D. S. Sinden, E. Q. Wei, A. S. Barnett, K. Johnson, A. Rubio-Navarro, A. K. Li, S. O. Marx, T. E. McGraw, , G. S. Pitt

This study identifies multiple beta cell-independent mechanisms causing hypoglycemia in Timothy syndrome using a novel mouse model.

bioRxiv · Jun 16, 2023Physiology

Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy

Y. Ye, E. R. Tyndall, V. Bui, M. C. Bewley, G. Wang, X. P. Hong, Y. Shen, J. M. Flanagan, H.-G. Wang, F. Tian

This study determines the solution structure of human Atg3 and shows how its dynamic regions and membrane interactions facilitate LC3-PE conjugation during autophagy.

bioRxiv · Dec 23, 2022 · PreprintBiochemistry

Curvature Sensing and Membrane Remodeling of the VPS37A N-terminal Domain during Autophagy

Y. Ye, X. Liang, G. Wang, M. C. Bewley, X. Liu, J. M. Flanagan, H.-G. Wang, Y. Takahashi, F. Tian

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

bioRxiv · Nov 1, 2022 · PreprintBiochemistry

Iron Inhibits Glioblastoma Cell Migration and Polarization

G. Shenoy, S. Kheirabadi, Z. Ataie, K. Palsa, Q. Wade, C. Khunsriraksakul, V. Khristov, B. Slagle-Webb, J. Lathia, H.-G. Wang, A. Sheikhi, J. R. Connor

This study shows that increasing cellular iron content reduces migratory capacity and polarization in human glioblastoma cells, with CDC42 expression being affected.

bioRxiv · Oct 13, 2022Cancer Biology

Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation

S. Zhou, X. Liu, X. Fang, V. M. Chinchilli, M. Wang, H.-G. Wang, N. V. Dokholyan, C. Shen, J. J. Lee

The paper introduces a robust beta regression method for dose-response curve estimation and develops a web tool for its implementation.

bioRxiv · Nov 20, 2021Pharmacology & Toxicology

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

T. G. Flower, Y. Takahashi, A. Hudait, K. Rose, N. Tjahjono, A. Pak, A. L. Yokom, X. Liang, H.-G. Wang, F. Bouamr, G. A. Voth, J. H. Hurley

This study determines the structure of human ESCRT-I and shows it forms a helical assembly that scaffolds and mechanically drives membrane scission during HIV-1 budding.

Nature Structural & Molecular Biology · May 18, 2020Peer-reviewedBiophysics

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

K. E. Clements, T. Thakar, C. M. Nicolae, X. Liang, H.-G. Wang, G.-L. Moldovan

This study identifies E2F7 as a regulator of chemoresistance in BRCA2-deficient cells, showing its role in enhancing PARP inhibitor and cisplatin resistance through RAD51 upregulation.

bioRxiv · Apr 3, 2018Cancer Biology